夏寧邵

發布時間:2011-08-05         瀏覽次數:11492

Xia, Ning-Shao 夏寧邵,教授 博導

1995-2002, Associate Professor, Xiamen University, 2002-present, Professor and Director, Research Center for Medical Molecular Virology of Fujian Province, 2005-present, Professor and Director, National Institute of Diagnostics  and Vaccine Development in Infectious Diseases.

1995-2002 廈門大學生命科學學院 副教授, 2002-廈門大學生命科學學院教授、博導, 2005-國家傳染病診斷試劑與疫苗工程技術研究中心主任,閩江學者特聘教授,國家杰出青年基金獲得者。獲得國家技術發明二等獎、國家科技進步二等獎、福建省技術發明一等獎等多項科技獎勵。


Research Interesting

     Research and development of recombinant antigen, vaccine and diagnostic kits related to medical virus, and their molecular biology and immunology study. To facilitate rapid response against newly emerged infectious diseases and forecast of new infections emerging.

   醫學病毒相關基因工程抗原、診斷試劑、疫苗、單克隆抗體等研發和產業化,以及相關病毒的分子生物學、免疫學基礎研究。建立突發傳染病應急反應和新發傳染病預警技術體系。首次鑒定出戊肝病毒的2個中和表位,建立了完善的大腸桿菌類病毒顆粒表達技術平臺,研制成功戊肝疫苗,成為國際上第一個完成三期臨床試驗申報新藥的戊肝疫苗,已獲得國內外授權發明專利4項 。


Selected Publications:

1. Zhu FC, J Zhang, C Zhou, XF Zhang,SJ Huang, H Wang, CL Yang, HM Jiang, JP Cai,YJ Wang, X Ai, Y Hu, Q Tang, YL Xian, T Wu, YM Li, J Miao, H Ng, JW Shih, Xia NS*. Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomized, double-blind placebo-controlled, phase 3 trlial. Lancet, 376:895-902, 2010.

2. Guo QS, Yan Q, Xiong JH, Ge SX, Shih JW, Ng MH, Zhang J, Xia NS*. Prevalence of hepatitis E virus in Chinese blood donors. J Clin Microbiol. 48:317-8, 2010.

3. Zheng ZZ, Miao J, Zhao M, Yeo AET, Yu H, Zhang J and Xia NS*. Role of heat-shock protein 90 in hepatitis E virus capsid trafficking. J Gen Virol,  91, 1728-1736, 2010.

4. Li SW ,  Seetharaman J. ,  Yang CY, Gu Y , Zhang J , Du HL , Shih JWK , Cl Hew, Sivaraman J , and Xia NS.Dimerization of Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host Interaction. PLoS Pathogens. 5:e1000537, 2009.

5. Zhang J, CB Liu, RC Li, YM Li, YJ Zheng, YP Li, D Luo, BB Pan, Y Nong, SX Ge, JH Xiong, JW Shih, MH Ng, Xia NS*. Randomized-controlled phase II clinical trial of a bacterially expressed recombinant hepatitis E vaccine. Vaccine, 27:1869-1874, 2009.

6. Chen YX, K Qin, WL Wu, GQ Li, J Zhang, HL Du, MH Ng, JWK Shih, JSM Peiris, Y Guan, HL Chen, and Xia NS*. Broad cross protection against H5N1 avian influenza infection using monoclonal antibodies mapping to conserved viral epitopes. Journal of Infection Disease, 199:49-58, 2009.

7. Chen YX, Qin K, Wu WL, Li GQ, Zhang J, Du HL, Ng MH, Shih JWK, Peiris JSM, Guan Y, Chen HL, and Xia NS*. Broad cross protection against H5N1 avian influenza infection using monoclonal antibodies mapping to conserved viral epitopes, J Infect Dis, 199: 199:49-58,2009.

8. He SZ., Miao Ji, Zheng ZZ, Wu T., Xie MH, Tang M., Zhang Jun, Ng MH., Xia NS*. Putative receptor-binding sites of hepatitis E virus. J. General Virol., 89:245-249.2008.

9. Wu T., Wu X.L., Ou S.H., Lin C.X., Cheng T., Li S.W., Ng M.H., Zhang J., Xia NS*. Difference of T cell and B cell activation in two homologous proteins with similar antigenicity but great distinct immunogenicity. Mol Immunol, 44:3161-3266, 2007.