李少偉

發布時間:2011-08-12         瀏覽次數:8571


李少偉,博士  LI Shaowei, Ph.D.

教授,博士生導師Professor

結構疫苗學(Structural Vaccinology)

電話:+86-592-2880620

傳真:+86-592-2181258

E-mailshaowei@xmu.edu.cn


簡歷 (Education and Work experience)

1998年,廈門大學生物化學專業,學士學位;

2003年,廈門大學生化與分子生物學/動物學專業,博士學位;

2003年,廈門大學生命科學學院講師;

2006年,廈門大學生命科學學院副教授;

2011年,廈門大學生命科學學院/威尼斯人官方網址教授、博士生導師。

B.S. Biochemistry, Xiamen University, 1998

Ph.D.Biochemistry&Molecular Biology/Zoology, Xiamen University, 2003

Lecturer,School of Life Sciences, Xiamen University, 2003

AssociateProfessor, School of Life Sciences, Xiamen University, 2006

Professor,School of Life Sciences/School of Public Health, Xiamen University, 2011


研究領域 (Research Area)

基因工程疫苗研究與開發

重要傳染病病毒免疫表位的結構和功能研究

基于結構的分子模擬和分子設計

Research and development of recombinant human vaccine

Structural basis and functional implication for underlying immune epitopes of key infectious viruses

Structure-based molecular simulation and rational design for vaccine


代表性論文(Selected Publications)(* Corresponding author)

1.Gu Y, Tang X, Zhang X, Song C, Zheng M, Wang K, Zhang J,Ng MH, Hew CL, Li S*, Xia N*,Sivaraman J*.Cell Res. 2015 May;25(5): 604-20.

2.Li S, Zhang J, Xia N*. Curr Opin Virol. 2015Apr;11:130-136.

3.Wang D, Li Z, Xiao J, Wang J, Zhang L, Liu Y, Fan F, XinL, Wei M, Kong Z, Yu H, Gu Y, Zhang J, LiS*, Xia N*. PLoS One. 2015 Apr23;10(4):e0123944.

4.Li SW, Zhao Q, Wu T*, Chen S, Zhang J, Xia NS. Hum Vaccin Immunother. 2015;11(4):908-14.

5.Gu Y, Cao F,Wang L, Hou W, Zhang J, Hew CL,Li S*, Yuan YA*, Xia N*. Structure of aNovel Shoulder-to-Shoulder p24 Dimer in Complex with the Broad-SpectrumAntibody A10F9 and Its Implication in Capsid Assembly. PLoS One. 2013 Apr19;8(4):e61314.

6.Yang C, Pan H, Wei M, Zhang X, Wang N, Gu Y, Du H, ZhangJ,Li S*, Xia N*.Hepatitis E virus capsid protein assembles in 4Murea in the presence of salts.ProteinSci. 2013 Mar;22(3):314-26.

7.Tang X, YangC, Gu Y, Song C, Zhang X, Wang Y, Zhang J, Hew CL,Li S*, Xia N*,Sivaraman J*. Structural basis for the neutralization and genotype specificityof hepatitis E virus. ProcNatlAcad Sci U S A. 2011 Jun 21;108(25):10266-71.Epub 2011 Jun 3.

8.Yu H,LiS*, Yang C, Wei M, Song C, Zheng Z, Gu Y, Du H, Zhang J, Xia N.Homology model and potential virus-capsid binding site of a putative HEVreceptor Grp78. J Mol Model. 2011May;17(5):987-95. Epub 2010 Jul 14.

9.Li S, Tang X, Seetharaman J, Yang C, Gu Y, Zhang J, Du H,Shih JW, Hew CL, Sivaraman J*, Xia N*. Dimerization of Hepatitis E Virus CapsidProtein E2s Domain is Essential for Virus-Host Interaction.PLoS Pathog. 2009 Aug;5(8):e1000537. Epub 2009 Aug 7.

10.Yang K,LiS*, He F, Zhang J, Wei M, Pan H, Yang C, Xiong J, Zhang J, Xia N.Expression and Purification of Soluble HIV-1 Envelope Glycoprotein gp160 Mutantfrom Saccharomyces Cerevisiae.JBiosci Bioeng. 2009 Jul;108(1):5-10.

11.Yan Y,LiS*, Yang C, Luo W, Wang M, Chen Y, Luo H, Wu T, Zhang J,  Xia N.Prediction of a common neutralizing epitope of H5N1 avian influenza virus by insilico molecular docking.ChineseScience Bulletin. 2008.53(1).

12.Li S, Zhang J, Li Y, Ou S, Huang G, He Z, Ge S, Xian Y, PangS, Ng M, Xia N*. A bacterially expressed particulate hepatitis E vaccine:antigenicity, immunogenicity and protectivity on primates. Vaccine.2005 Apr 22;23(22):2893-2901.

13.Li S, Zhang J, He Z, Gu Y, LiuR, Lin J, Chen Y, Ng M, Xia N*. Mutational analysis of essential interactionsinvolved in the assembly of hepatitis E virus capsid.J Biol Chem. 2005Feb 4;280(5):3400-6. Epub 2004 Nov 22.


榮譽、獎勵及參加學術團體的情況(Honors and award):

2011年入選教育部新世紀優秀人才,2011年福建省杰出青年基金、2010年廈門市杰出青年基金;主持國家自然科學基金、“863”重點項目子課題、新藥創制重大專項及滾動項目等課題;獲得國家科技進步二等獎、國家技術發明二等獎、中國高校科技進步一等獎等;發表SCI論文40余篇,申請國家發明專利24項,國際發明專利12項,獲得授權7項;為主研制出戊肝疫苗、宮頸癌疫苗、艾滋診斷試劑等新藥。

WIPO-SIPO  Award for Chinese Outstanding Patented Invention (2012)

State   Technological Invention Award (2010)

State   Scientific and Technological Progress Award (2001)